Study Abstract:
Hemodynamic and autonomic effects of
smokeless tobacco in healthy young men.

Journal of the American College of Cardiology, March 2005 15;45(6): pages 910-914.


Wolk R, Shamsuzzaman AS, Svatikova A, Huyber CM, Huck C, Narkiewicz K, Somers VK.

Mayo Clinic, Rochester, Minnesota 55905, USA.

OBJECTIVES: The aim of this study was to investigate the acute hemodynamic and autonomic effects of smokeless tobacco.

BACKGROUND: Smokeless tobacco use is increasing. Its cardiovascular effects are not well understood.

METHODS: Sixteen healthy, male, habitual snuff tobacco users (aged 22 1 year) were studied, using a randomized, double-blind, placebo-controlled, crossover design with two separate experimental sessions: placebo and tobacco. Muscle sympathetic nerve activity (MSNA), electrocardiogram, blood pressure, calf blood flow, nicotine, and catecholamines were measured.

RESULTS: Snuff tobacco increased plasma nicotine from 2.8 0.5 ng/ml to 10.4 1.1 ng/ml. Mean blood pressure increased by 10 1 mm Hg, and heart rate increased by 16.2 beats/min. Peripheral vascular resistance, MSNA, and norepinephrine concentration did not change with tobacco, but epinephrine increased by approximately 50%.

CONCLUSIONS: Oral snuff tobacco increases heart rate, blood pressure, and epinephrine. Despite the increase in blood pressure, there is no decrease in either MSNA or peripheral vascular resistance. Smokeless tobacco is a powerful autonomic and hemodynamic stimulus. Catecholamine release from the adrenal medulla likely contributes to this response.

PMID: 15766828 [PubMed - in process]

http://www.ncbi.nlm.nih.g...t&list_uids=15766828


Edited 1 time by JohnPolito Apr 8 11 9:21 AM.