Like most of you, I gave blood many times while a smoker.  What I didn't then know was that if I had smoked within the past 24 hours that my blood was loaded with far too much vascular endothelial growth factor or VEGF.   Too much VEGF contributes to disease in many ways,  including artery hardening and accelerating tumor growth rates.  So you see, if the person who received my blood was in ICU battling circulatory disease or at a make or break  point in their cancer treatment, receiving my blood was less than ideal.  

It isn't pretty discovering and unfolding all the negatives associated with my 30 years of bondage.  I cannot undo what's been done.  What I can do is, just one day at a time, is to allow life not drugs to control the quality of the blood flowing within these veins.  If just starting out, baby steps and soon you too will reside here on Easy Street with us.    Still just one rule ... no nicotine today!

Breathe deep, hug hard, live long,

John (Gold x11)   


Time interval from cigarette smoke exposure to
blood donation and markers of inflammation:
should a smoking cut-off be designated?

Xenobiotica. 2010 Jul 5. [Epub ahead of print]

Symvoulakis EK, Vardavas CI, Fountouli P, Stavroulaki A, Antoniou KM, Duijker G, Tzatzarakis MN, Sfiridaki K, Bolonaki E, Alegakis T, Tsatsakis AM.

Abstract

Allogeneic blood transfusion leads to the infusion into the recipient of large amounts of antigens that may create conditions which are related to immune system modulation. The aim of this study was to determine the effects of smoking habit on vascular endothelial growth factor (VEGF) and interleukin 6 (IL-6) levels in the plasma of blood donors.

Blood samples from 170 consecutive blood donors was collected and analyzed for serum markers, while questionnaire data was collected. Serum cotinine levels were calculated for non-smokers, while serum cytokine IL-6 and VEGF concentrations were also calculated among 88 randomly selected subjects.

Controlling for the donors age and gender, a strong tendency was found for smoking within 24 h of the blood donation to be associated with a higher VEGF concentration of the donated blood (beta = 141.13, p = 0.06), while the donor age was independently related to VEGF levels (p = 0.001). Additionally the IL-6 levels in the transfused blood were independently associated with the donors age (p = 0.001) and gender (p = 0.002) but not with their smoking status.

Further research is needed so as to assess the need of updating blood donation guide lines to regulate the time intervals between the time from the last cigarette and blood donation.

http://informahealthcare.com/doi/abs/10.3109/00498254.2010.500745


Edited 1 time by JohnPolito Jul 17 10 9:02 AM.